Version of Record online: 19 SEP 2017 | DOI: 10.1002/cmdc.201700537
The front cover picture shows
a lactam-bridged peptide scaffold that arranges three hydrophobic
groups (acetyl, isobutyl, isobutyl) over two helical turns. These groups
mimic three-residue hydrophobic patterns of the helical regions of the
helix-loop-helix transcription factors Id (inhibitors of DNA binding and
cell differentiation). This cyclopeptide, which has micromolar affinity
for its Id-protein target, can penetrate the cancer cell membrane,
accumulate in the nucleus, and induce cell growth inhibition and cell
death in the micromolar range. The superhero was drawn by Hannah Vulcana
Kriechbaum + with help from Mag. Cornelia Roschger (www.hannahvulcana.blogspot.com). More information can be found in the Full Paper by Chiara Cabrele et al. on page 1497 in Issue 18, 2017text online
http://onlinelibrary.wiley.com/doi/10.1002/cmdc.v12.18/issuetoc
